Curiously, in one of those reports (Tanganelli et al 1995) destruction of serotonin neurons by using a selective neurotoxin, did not basically block modafinil’s GABA inhibiting consequences but brought about modafinil to enhance cortical GABA. It appears that With this study the GABAergic neurons were strongly inhibited by a serotonergic system a
In vitro, modafinil has actually been revealed to bind weakly but selectively on the dopamine transporter (Mignot et al 1994; Nishino et al 1998; Madras et al 2006) and, to a lesser extent, the norepinephrine transporter (Madras et al 2006). Wake-endorsing concentrations of modafinil improved extracellular amounts of monoamines, such as norepinephr
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